While the opposites of these such as Nocturnal and Phengophobia I always remove as soon as possible. Some negative quirks like Diurnal or Night Blindness I leave alone since I play with the lights usually above 50 if possible. I'd typically dismiss people if they have too many negative quirks as to be ineffective in their roles such as a tank having Soft (-10% HP) or a shooter with Flawed release (-3% ranged crit) Crusader with Unholy Hater, Unholy Slayer

Bountyhunter with Mankind Hater, Man Slayer Houndsman with Beast Hater, Beast Slayer Occultist with Eldritch Hater, Eldritch Slayer Unerring (+10 ranged damage), Eagle Eye (+3% ranged Crit), Natural Eye (+5 ranged Acc) for my shooters. Slugger (+10% melee damage), Precise Striker (+3% melee Crit), Natural Swing (+5 Acc) is the set for my melee damage dealers. Tough (+10% HP), Hard Skinned (+10% Prot), Steady (-10% Stress) is my go to lock-ins for my front liners. I do have a set of 'standard' quirks though, but that could change depending on the situation.

Darkest dungeon crusader quirks